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HAYA Therapeutics

HAYA Therapeutics is a precision medicines company developing RNA-guided programmable therapeutics targeting the regulatory genome for serious health conditions including cardiovascular disease and cancer. The company is using its innovative cell-state modifying platform to gain novel insights into the biology of long non-coding RNAs (lncRNAs), the ‘dark genomes’ information processing features and ‘source code’. HAYA’s lead therapeutic candidate is HTX-001, an antisense oligonucleotide targeting Wisper, which is a tissue and cell-specific cardiac lncRNA known to play a role in heart failure. The company is also developing a pipeline of lncRNA-targeting candidates for the cell-specific treatment of diseases in other tissues, including the lungs and the microenvironment of solid tumor cancers. Headquartered at the life sciences park Biopôle in Lausanne, Switzerland with laboratory facilities at JLABS @ San Diego, HAYA is led by a world-class team of experts in programmable and precision RNA-targeted therapeutics and is supported by a strong investor consortium. HAYA’s mission is to identify and develop breakthrough disease-modifying therapeutics with the potential for greater efficacy, safety, and accessibility than existing treatments.

http://www.hayatx.com
11-50 employees

Growth Trajectory

Haya Therapeutics aims to grow by expanding its pipeline to address more diseases, including heart, lung, tumor microenvironment, liver, pancreas, and kidney indications. Partnerships with biopharma companies will be crucial for market expansion, and they are actively hiring to support this growth. The company's innovation focus lies in advancing RNA-targeting modalities and data integration platforms.

Technical Challenges

Targeting and modulating lncRNAs within the dark genome.
Ensuring security, confidentiality, integrity, and availability of data, mitigating risks of loss, alteration, unauthorized disclosure or access.
Complexity and resistance of solid tumors to traditional treatments, immunosuppressive tumor microenvironment.

Tech Stack

lncRNA BiologyRegulatory genomeASO technologiesCirculating biomarkersMulti-omics data analysisIntegrationGenome modulation technologiesRNA platformDiscoverHAYA™ drug discovery engineWebflowGoogle AnalyticsLinkedIn

Team Size

Scientists
Bioinformaticians
Vice President, Translation
Board of Directors

Key Risks

Reliance on partnerships with biopharma companies for disease and modality expertise poses a risk if these partnerships are not secured or successful.
Challenges in targeting and modulating lncRNAs within the dark genome could hinder therapeutic development.
Competition in the broader RNA therapeutics landscape may impact market share and adoption.
Potential data security breaches despite security measures, impacting customer trust and regulatory compliance.
Delivery & Safety concerns as BIO-Europe plumbs future of gene therapy.

Opportunities

Leverage the unexplored therapeutic potential of the dark genome and lncRNAs to develop first-in-class therapeutics.
Expand the pipeline to address a wider range of diseases, including fibrosis, cardiovascular diseases, obesity, and metabolic conditions.
Forge partnerships with biopharma companies to leverage their disease and modality expertise.
Advance RNA-targeting modalities and drug discovery platforms to enhance therapeutic efficacy and safety.
Provide transparent data processing and privacy practices.
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